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Primary hyperparathyroidism and other causes of calcium elevation, including ectopic hyperparathyroidism (pseudohyperparathyroidism).

The signs and symptoms of phosphate depletion may include neuromuscular, neuropsychiatric, gastrointestinal, skeletal, and cardiopulmonary systems. Manifestations usually are accompanied by serum levels <1.0 mg/dL.

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Phosphorus has many important roles:

Helps build cells, DNA, and proteins
Crucial for strong bones and teeth
Vital for energy metabolism, as the “P” of ATP – the “energy currency” of our cells
Required for muscle contractions and sending out nerve signals
As the most abundant anion (negative ion) in the body, phosphate helps maintain the acid-base balance (pH)
Blood phosphate comprises a very small part of total body phosphate, nevertheless, it gives a good estimate of phosphate levels in the body.

Phosphorus metabolism is tightly bound to that of calcium – both minerals are affected by the same hormones, usually in the opposite direction. In addition, phosphate can bind calcium in the blood, thereby reducing its levels. Our health depends on a delicate balance between these two minerals.

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